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APOPTOSIS INDUCING FACTOR
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DeCS
Descriptor
English
:
Apoptosis Inducing Factor
Descriptor
Spanish
:
Factor Inductor de la Apoptosis
Descriptor
Portuguese
:
Fator de Indução de Apoptose
Synonyms
English
:
AIF Apoptosis Regulatory Protein
Apoptosis-Inducing Factor
Mitochondrial Apoptosis-Inducing Factor
Apoptosis-Inducing Factor, Mitochondrial
Mitochondrial Apoptosis Inducing Factor
Tree Number:
D08.811.682.608.047
D12.644.360.075.311
D12.776.331.161
D12.776.476.075.311
Definition
English
:
A
flavoprotein
that functions as a powerful antioxidant in the
MITOCHONDRIA
and promotes
APOPTOSIS
when released from the
mitochondria
. In mammalian cells AIF is released in response to pro-apoptotic protein members of the bcl-2 protein
family
. It translocates to the
CELL NUCLEUS
and binds DNA to stimulate CASPASE-independent
CHROMATIN
condensation.
Indexing Annotation
English
:
INHIBITOR OF APOPTOSIS PROTEINS
is also available
History Note
English
:
2006(1999)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
50601
Unique Identifier:
D051033
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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